GENE THERAPY Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity
نویسندگان
چکیده
1Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; 2Department of Cell Growth and Cancer Regulation, Ehime University Proteomedicine Research Center, Ehime, Japan; 3Takara Bio Inc Center for Cell and Gene Therapy, Shiga, Japan; 4Division of Immunology, Aichi Cancer Center, Aichi, Japan; 5Department of Cancer Vaccine and Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan; 6Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; 7Department of Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, United Kingdom; and 8Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan
منابع مشابه
Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity.
Aurora kinase A (AURKA) is overexpressed in leukemias. Previously, we demonstrated that AURKA-specific CD8(+) T cells specifically and selectively lysed leukemia cells, indicating that AURKA is an excellent target for immunotherapy. In this study, we examined the feasibility of adoptive therapy using redirected T cells expressing an HLA-A*0201-restricted AURKA(207-215)-specific T-cell receptor ...
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Aurora Kinase A is a cancer-associated protein normally involved in the regulation of mitosis. Being over-expressed in a range of cancers, it is a suitable target for cell-based immunotherapy. Gene transfer of T-cell receptor sequences cognisant of HLA-A*0201-restricted Aurora Kinase A antigen has previously been shown to transfer specific immunoreactivity against the target peptide in a Human ...
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